![]() ![]() These elements have grown more complex as evolution scaled the phylogenetic tree. The human genome is characterized by a high degree of structural and behavioral variability: DNA content variation, epistasis, stochasticity in gene expression, and epigenetic changes. Thus, the origins of neuropsychiatric disorders in particular and complex disease in general have been illuminated. Techniques for higher resolution, genomewide analysis have begun to illuminate the irregular and unpredictable behavior of the human genome. Such irregularities reflect the problem of missing heritability although hundreds of genes may be associated with autism or schizophrenia, together they account for only a small proportion of cases. Also, autism and schizophrenia occur on a spectrum of severity, from mild and subclinical cases to the overt and disabling. The genetic origins of such conditions are confounded by the problem of variable expression, that is, when a given genetic aberration can lead to any one of several distinct disorders. Autism and schizophrenia defy a principle of natural selection they are highly heritable but associated with low reproductive success. ![]() ![]() ![]() Twentieth-century genetics was hard put to explain the irregular behavior of neuropsychiatric disorders. ![]()
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